Generic vs branded medicines: an over-view

Swapna Mandapati

Mandapati Swapna Priyadharshini Institute of Pharmaceutical Education and Research, 5th Mile, Pulladigunta, Guntur- 522017, Andhra Pradesh, India.
swapnamandapati7@gmail.com

Abstract

The Indian pharmaceutical industry is the winner in the form of the most affordable formula in the world. The concept of generic prescription is widely accepted in various parts of the world. Nevertheless, it has failed to gain popularity in INDIA due to factors such as no availability and distrust on the product quality. However, since 2012, the Government of West Bengal, India, has initiated exclusive generic drug outlets called “fair price medicine shop” (FPMS).The concept of generic prescription is widely accepted in various parts of the world Generic drugs offer the same ingredients and same dosage forms therapeutic effect but lower cost and there available after the brand name drug patent expires .Dissolution is the amount of substance that goes into solution per unit time under standardized conditions of liquid/solid interface, solvent composition and temperature. Dissolution is one of the most important tools to predict the in-vivo bio-availability and in some cases to determine bioequivalence and assure interchange ability. Same drug can be sold for different prices under different brand names due to various reasons. Branded medicine is the original product that has been developed by a pharmaceutical company and generic medicine is a copy of the original branded product, marketed after the expiry date of the patent and hence supposed to be of low cost as compared to their branded versions

Keywords: In-vitro dissolution, Absorption, Difference between the branded vs generic medicines, Dissolution Method, IVIVC

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References

1. Roberts R, Maldonado S. FDA center for drug evaluation and research (CDER) pediatric plan and new regulations. Drug information journal. 1996 Oct;30(4):1125-7.
https://doi.org/10.1177/009286159603000430
2. Hwisa NT, Gindi S, Rao CB, Katakam P, Rao Chandu B. Evaluation of Antiulcer Activity of Picrasma Quassioides Bennett Aqueous Extract in Rodents. Vedic Res. Int. Phytomedicine. 2013;1:27.
https://doi.org/10.1002/bmb.20934
3. Mutlu A. Comparison of two different techniques of cooperative learning approach: Undergraduates' conceptual understanding in the context of hormone biochemistry. Biochemistry and Molecular Biology Education. 2018 Mar;46(2):114-20.
http://e-currentscience.com/journal/e/CTPPC
4. Gindi S, Methra T, Chandu BR, Boyina R, Dasari V. Antiurolithiatic and invitro anti-oxidant activity of leaves of Ageratum conyzoides in rat. World J. Pharm. Pharm. Sci. 2013 Feb 8;2:636-49.
https://doi.org/10.24092/CRPS.2019.090402
5. Cameron A, Mantel-Teeuwisse AK, Leufkens HG, Laing RO. Switching from originator brand medicines to generic equivalents in selected developing countries: how much could be saved?. Value in health. 2012 Jul 1;15(5):664-73.
https://doi.org/10.1016/j.jval.2012.04.004
6. Nikam NR, Vakhariya RR, Magdum CS. Generic Vs. Brand Medicines: An Overview. Asian Journal of Pharmaceutical Research. 2019;9(2):109-15.
https://doi.org/10.24092/CRPS.2019.090402
7. Bera A, Mukherjee A. The importance of generic drugs in India. Int J Pharm Chem Biol Sci (IJPCBS). 2012;2(4):575-87.
https://doi.org/10.30574/wjbphs.2021.7.2.0086
8. Arora K, Singh S, Singh PK. A review on Generic and Branded Drugs-Competence of generic drugs in comparison to branded drugs. Current Research in Pharmaceutical Sciences. 2019:63-6.
https://doi.org/10.24092/CRPS.2019.090402
9. Midha KK, McKay G. Bioequivalence; its history, practice, and future. The AAPS journal. 2009 Dec;11:664-70.
https://doi.org/10.1177/009286159903300215
10. Mathew P. Generic drugs: Review and experiences from South India. Journal of family medicine and primary care. 2015 Jul 1;4(3):319-23.
https://doi.org/10.1177/0972063417747747
11. Nagappa AN, Kavya HB, Chikkamath V, Naik VB. S generic-value based pricing for pharmaceutical in India. Juniper Online J Case Stud. 2017;4:2-4.
https://doi.org/10.1185/030079907X233395
12. Singal GL, Nanda A, Kotwani A. A comparative evaluation of price and quality of some branded versus branded-generic medicines of the same manufacturer in India. Indian journal of pharmacology. 2011 Mar 1;43(2):131-6.
https://pubmed.ncbi.nlm.nih.gov/21572645/
13. Kipgen J. Sex-Selective Abortion in India: Social Structures, Women’s Agency, and Media Discourse. University of Kansas; 2020.
https://doi.org/10.1007/978-3-031-44176-9_1
14. Mutlu A. Comparison of two different techniques of cooperative learning approach: Undergraduates' conceptual understanding in the context of hormone biochemistry. Biochemistry and Molecular Biology Education. 2018 Mar;46(2):11420
https://iubmb.onlinelibrary.wiley.com/doi/full/10.1002/bmb.21097
15. Agarwal DS, Chairman DT. Central drugs standard control organization. New Delhi. 2017.
https://doi.org/10.37022/jpmhs.v3i2.21
16. Jenei K. The Political Economy of the World Health Organization Model Lists of Essential Medicines. The Milbank Quarterly. 2025 Mar.
https://doi.org/10.1111/1468-0009.70001
17. Sharma AK, Shrivastava TP, Singh MA, Ahuja J, Goyal RK. Regulations in India. InGlobal Regulations of Medicinal, Pharmaceutical, and Food Products 2024 (pp. 133-152). CRC Press.
https://doi.org/10.62823/EXRE/2024/01/01.5
18. Alfaqih MA, Khader YS, Bashir N, Nusair Z, Nuseir Q, Nusier M. Attitude of Jordanian Sphysicians toward biochemistry and genetics. BioMed Research International. 2019;2019(1):3176951.
https://doi.org/10.62823/EXRE/2024/01
19. Nama S, Chandu BR, Awen BZ, Khagga M. Development and validation of a new RP-HPLC method for the determination of aprepitant in solid dosage forms. Tropical Journal of Pharmaceutical Research. 2011;10(4):491-7.
https://doi.org/10.62823/EXRE/2024/01/01.5
20. Kiranmai M, Renuka P, Brahmaiah B, Chandu BR. Vitamin D as a promising anticancer agent.
http://e-currentscience.com/journal/e/CTPPC