A Case Report on Organic Psychosis Induced by Antitubercular Drugs in A Young Female
Case report of drug induced organic psychosis
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Prakash Nathaniel Kumar Sarella
Associate Professor, Aditya College of Pharmacy, Surampalem, AP - 533437.
sarellaprakash@acop.edu.in
- Janki Pavanilakshmi Dadishetti Department of Pharmacy Practice, Government General Hospital, Kakinada, Andhra Pradesh-533001, India.
- Patrick Oliver Asogwa Department of Pharmacology, Aditya College of Pharmacy, Surampalem, Kakinada, Andhra Pradesh-533437, India.
- Ravishankar Kakarparthy Department of Pharmacology, Aditya College of Pharmacy, Surampalem, Kakinada, Andhra Pradesh-533437, India.
Abstract
Antitubercular drugs including rifampicin, isoniazid and pyrazinamide can cause rare but severe adverse effects involving the central nervous system. Neuropsychiatric side effects ranging from headache to psychosis have been reported. Early identification and management is crucial to improve outcomes. We report the case of a 26-year-old female with a history of tuberculosis who developed symptoms of organic psychosis after taking antitubercular drugs for 45 days. She presented with altered sensorium, seizures, sensory and memory loss. Diagnosis of drug-induced psychosis was made based on the temporal association and exclusion of other causes. Symptoms resolved after discontinuation of the culprit medications. Clinicians should be aware of neuropsychiatric adverse effects of antitubercular drugs which though rare can be serious. Timely diagnosis and withdrawal of the offending medications are needed to improve outcomes in such cases.
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